If this is permanent and we somehow knew it wasn't going to return?
First i would be armed in about five different ways. Then I would head south into the fields and eventually the lakes of the Ozarks. I would never go near a roadway and I would avoid farms and such along the way. I may swing slightly east before heading south and link up with a FWB I have in Missouri who was in the army and I know can manage in the field.
I would then fish and start salting it for winter. Scout out the areas I find to sleep and find the local wild plants that you can eat... if this happened now that is because first job will be to make it through winter. After the first winter, I would hunt enough to make some rations for the road and then head west and north. North because those unprepared will not survive a cold winter and west because that is where most of our largest natural preserves are located.
This is fun to plan... can I turn the switch off and get started now?