Rick Florino of Artistdirect gave the song four and half stars, calling it "one of Britney's catchiest club bangers yet" and saying "[it] proudly stands alongside Britney classics like 'Womanizer,' 'Gimme More,' and 'Toxic,' but there's a refined ethereal elegance to it that sees Britney stepping into new territory and pushing the boundaries of dance pop once more."
Rob Sheffield of Rolling Stone compared the song's riff to AC/DC's "Dirty Deeds Done Dirt Cheap" (1976), and referred to the song as "prime Britney."
Jim Farber of the Daily News said that the song is reminiscent of Spears's previous hits, noting the double entendre lyrics and arrangement, and added, "With all that behind her, the 'Oops' girl may yet do it again."
Bill Lamb of About.com called it one of the most mature dance pop songs of Spears's career, praising the chorus structure and the electropop bridge. Lamb stated, "The pop music of 2011 has an early shot in the arm here. ['Hold It Against Me'] will quickly take its place among Britney Spears' best singles."
Popjustice positively compared the song to the leaked demo, saying that while the lyrics and melody were not different, Spears's finished version "is approximately 1000 times better than the demo. It's a harder, more urgent, extremely epic statement track that sounds like the work of a superstar."
"...With "Hold It Against Me" already under her belt and making a lot of noise, expect Spears to have one of the biggest years of any artist out there — and perhaps of all time." ~MTV.COM
Brad Wete of Entertainment Weekly said "'Against Me' [sic] is classic Britney —
that is to say the vocal performance is far from stellar, but it serves as a nice accessory to [Luke and Martin]'s thumping Euro techno groove." He also added that
Spears did not enter any new territory lyrically, and that
there was not much growth when compared to singles such as "...Baby One More Time" [1998] or "I'm a Slave 4 U" (2001).
Greg Kot of the Chicago Tribune commented, "It’s one of the tougher-sounding Spears singles yet and
should do the job as a dancefloor-filler for listeners who are starting to wear out on the latest singles from Katy Perry and Black Eyed Peas". However,
he also dismissed the lyrical content and said that Spears sounds "bored [...] as is the case with most of her recent work."
Nick Levine of Digital Spy said that although "Hold It Against Me" was produced by Luke and Martin, the finished product was not similar to songs by regular collaborators Kesha and Katy Perry. He also deemed it as "clubby and au courant",
while comparing it to Rihanna's "Only Girl (In the World)" (2010).
Jim Cantiello of MTV commented that "Hold It Against Me" combines the electronic sound of contemporary radio with a "sing-songy" chorus that references Spears's bubblegum pop past.
Edna Gundersen of USA Today criticized the use of pick-up lines, but said the single "delivers enough dizzying dance-pop ecstasy to ensure another chart-topping ride."
Glenn Gamboa of Newsday stated that "Hold It Against Me" was "a bit safer [...] like her current low-key, non-tabloid persona."
Michael Cragg of The Guardian called it "decent enough."
The Globe and Mail's J.D. Considine called the reworking of The Bellamy Brothers' song "lame", but concluded that the track was "perfect ear candy", calling it "lust made audible".
Spears's vocals has been described as
"a bit treated - it's a Britney single" but not heavily
Autotuned.
The hook was noted by Ann Powers of Los Angeles Times to be reminiscent of "(I Just) Died in Your Arms" (1986) by Cutting Crew.